This is a tough Week 1 matchup for Arizona with their offensive unknowns since Washington has one of the best defenses in the NFL. Kyler Murray (knee) opens the season on the PUP list and they released their top receiver, DeAndre Hopkins, making offense hard to come by on Sunday. 1 pick in the 2023 NFL Draft after going 4-13 this season. One of the model's strongest Week 1 NFL picks is that the Commanders (-7) cover against the Cardinals. Now, it has turned its attention to the latest Week 1 NFL odds and locked in picks for every NFL matchup. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. It is also on a 17-6 roll on top-rated NFL picks since Week 7 of last season. The model enters the 2023 NFL season on an incredible 163-113 run on top-rated NFL picks that dates back to the 2017 season. The model, which simulates every NFL game 10,000 times, is up over $7,000 for $100 players on top-rated NFL picks since its inception.

Are they being underestimated yet again and should you include them in your Week 1 NFL picks? All of the Week 1 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Week 1 NFL picks now. The Giants are 3.5-point home underdogs against the Cowboys on Sunday Night Football in the latest Week 1 NFL odds.

The Giants (14-5) had the best record against the spread last season, including the playoffs, but they won't be surprising many as underdogs this season. The parity is evident when looking at the Week 1 NFL odds, so who can you feel confident in? Seven of the 15 remaining Week 1 games have the favorite listed at -3 or lower in the NFL Vegas odds. Every team wants to think its offseason moves will either help them remain toward the top or become a Cinderella, defying NFL spreads week after week. When you look at the Week 1 NFL schedule, teams are full of optimism. The 2023 NFL season is here and Week 1 can be the toughest week for oddsmakers and sports bettors looking to make their picks based on the Week 1 NFL odds.

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